X - linked dominant is a rare way a trait or disorder can be passed down through families. The trait is caused from a mutation on the X chromosome. One copy of a disease allele is required for the individual to be susceptible to the disease.
The gene is located on the X chromosome therefore a male cannot have a transmission to a son. All daughters of an affected male will be affected and all children of an affected female will have a fifty percent chance. Families with an X - linked dominant disorder usually have affected males and females in each generation.
Oral Facial Digital Syndrome Type 1 is inherited in an X linked manner. The abnormal features are oral, facial, digital, brain, and kidney related. Some of the characteristics include cleft palate, cleft lip, extra fingers, intracerebral cysts, and polycystic kidney disease. Additionally fifty percent of those with the disease have a mild intellectual or learning disability. Most cases do not have a family history of the disease. When a mother is affected one third of the female offspring will be unaffected, one third of the females will be affected and one third of males will be unaffected. Therefore there is a very small chance of a male having this disease. Surgery or routine treatment can help fix many of the characteristics of OFD1.
To learn more about X-linked dominant transmissions click here- http://www.nlm.nih.gov/medlineplus/ency/article/002050.htm
To learn more about OFD1 click here- http://www.ncbi.nlm.nih.gov/books/NBK1188/
To learn more about OFD1 click here- http://www.ncbi.nlm.nih.gov/books/NBK1188/